Youth perspectives to inform the next generation of HIV biomedical HIV prevention.
Pre-exposure prophylaxis (PrEP) is a highly effective, biomedical mode for HIV prevention offered as a daily oral tablet that if taken with high adherence, provides protection against HIV infection if exposed via sexual contact and/or drug use. While adolescents and young adults (ages 15-29 years) are disproportionately infected with HIV in the United States, PrEP uptake has been low. Young people who are currently taking PrEP have demonstrated low adherence to PrEP, compromising the potential effect of the drug in preventing seroconversion. To help offset challenges linked to uptake and daily adherence, HIV prevention scientists are actively developing and testing the efficacy of next generation PrEP formulations, including episodic oral PrEP, products offering systemic protection (e.g., douche, implants), injectables administered monthly or less often, and vaccines. Diverse modalities for delivery provide choices for HIV prevention/sexual health promotion that are congruent with sociocultural context (e.g., values, preferences, and sexual practices). To date, few studies have been able to capture youth perspectives on product preferences and acceptability that may assist youth at high risk of HIV to overcome challenges to adopting highly effective HIV prevention strategies.
The Next Choices study seeks to employ mixed methods to accomplish the following aims:
Content analyze social media content to describe youth's discussions of behaviorally-congruent behaviors related to HIV prevention (e.g. douching, HIV/STI testing, PrEP) to inform message framing of next generation biomedical prevention;
Conduct up to 20 cognitive interviews to improve measures and methods to assess youth’s preferences for diverse HIV prevention products in acceptability surveys;
Examine via a web survey (N≈1,500) youth’s acceptability of next generation biomedical prevention, including the use of conjoint analyses to ascertain youth’s choices based on product characteristics (e.g., delivery modality, hypothetical efficacy, behavioral congruence).